Chemistry of Natural Products ppt

is a chemical compound or substance produced by a living organism - found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design.
A natural product can be considered as such even if it can be prepared by total synthesis.

STEREOCHEMITRY

The study of the static and dynamic aspect of the three dimensional shapes of molecules.
Objective

After completion of this chapter students will be able to:
describe the impact of the 3-D structure of compounds on their biological activity
define and classify isomerism
mention the causes of chirality
identify chirality centers
define optical activity
calculate specific rotation….
differentiate between stereoisomers
convert 3-D to 2-D
designate R/S configuration for molecules
explain resolution of racemic mixtures
discuss the significance of stereoisomerism in determining drug action and toxicity


CONTENTS

Isomerism
Chirality
Enantiomers
Optical activity
Racemic mixtures
Meso-Compounds
R/S configuration
Diastereomers
Fisher projection
Configuration and conformation

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